Recent Developments in Pharmacokinetic and Pharmacodynamic Modeling and Data Analysis
Presenter: Hulin Wu
When: Tuesday, July 12, 2016 Time: 11:00 AM - 12:30 PM
Room: Salon A Carson Hall (Level 2)
Session Synopsis:
Multiscaling Modeling for PK/PD Studies
It is very important to incoporate data and biological mechanims at genetics, protein and cellular leveles of diseases and intervetions into PK/PD modeling so that the complex host system response to intervention drugs can be modeled and integrated. In this talk, I will discuss novel mathematical models, computational techniques, and statistical methods to rigorously identify a high-dimensional multiscale systems biology model based on experimental data, and how to incorporate the multiscale dynamic models with PK/PK models to quantify drug responses. I will present our recent work on how to construct high-dimensional dynamic models to describe a multiscale system for host response to treatment interventions. A Big Data processing and integration pipeline for time course high-throughput data at transcriptomic, proteomic, molecular and cellular levels will be discussed.
Recent Developments in Pharmacokinetic and Pharmacodynamic Modeling and Data Analysis
Presenter: Martin Lysy
When: Tuesday, July 12, 2016 Time: 11:00 AM - 12:30 PM
Room: Salon A Carson Hall (Level 2)
Session Synopsis:
BAYESIAN INFERENCE AND UNCERTAINTY QUANTIFICATION FOR STOCHASTIC PK/PD MODELS
Differential Equations (DEs) occupy a central role in the modeling of many pharmacokinetic and pharmacodynamic (PK/PD) processes. To estimate the parameters of these equations, a statistical approach constructs a likelihood function by augmenting the deterministic DE with a stochastic simulation model. We present a Bayesian methodology and its software implementation for PK/PD parameter inference, accounting for three sources of stochastic variability: (1) instrumental measurement error, (2) intra-subject process fluctuations, and (3) between-subject random effects. Through numerical experiments, we explore the effect of increased model complexity on the bias-variance trade-off.
Recent Developments in Pharmacokinetic and Pharmacodynamic Modeling and Data Analysis
Presenter: Jose Pinheiro
When: Tuesday, July 12, 2016 Time: 11:00 AM - 12:30 PM
Room: Salon A Carson Hall (Level 2)
Session Synopsis:
Recent Developments in Pharmacokinetic and Pharmacodynamic Modeling and Data Analysis
Presenter: Sophie Donnet
When: Tuesday, July 12, 2016 Time: 11:00 AM - 12:30 PM
Room: Salon A Carson Hall (Level 2)
Session Synopsis:
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